Daylen Harrsion led the Eagles (1-1) with 14 points and nine rebounds and Glenn Bryan chipped in with 13 points.
Gamecocks (2-0) Darion Rackley scored a game high 17 points for Jacksonville State.
EMU took the lead 44-43 with 6:42 left, but then were outscored 18-10 down the stretch.
The Eagles will next play three-games-in-three-days in the inaugural EMU "Ice Man" Classic. The Green and White will first host Eastern Illinois at 7 p.m., this Friday in the three-day tournament. All games will be played in the Convocation Center.
Radio: The game will be broadcast on WEMU-FM (89.1).